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We conducted a systematic review and random-effects meta-analysis of 18 randomized controlled trials (N = 4,120) evaluating intervention X versus standard of care. Pooled analysis demonstrated a statistically significant reduction in the primary composite endpoint (RR 0.84, 95% CI 0.72–0.98, p = 0.03; I^2 = 68%). However, when restricted to the 6 double-blind trials with low risk of bias (N = 1,890), the effect was attenuated and no longer statistically significant (RR 0.96, 95% CI 0.85–1.08).
**Caution — Conflicted Evidence**:
1. **Headline vs Rigorous Subgroup**: While the pooled 18-trial result barely reached significance (`RR 0.84, p = 0.03`), heterogeneity was high (`I^2 = 68%`).
2. **Crucial Caveat**: In the **6 double-blind, low-risk-of-bias trials (`N = 1,890`)**, the benefit vanished (`RR 0.96, 95% CI 0.85–1.08`, crosses 1.0).
3. **How to Cite It**: Cite it as showing that open-label/higher-bias trials reported an effect that was *not replicated* in double-blind trials.
Click into the paper landing page linked from Google Scholar (PubMed, ScienceDirect, Springer, arXiv) and highlight the abstract or methods preview.
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| Workflow | Strengths | Tradeoffs |
|---|---|---|
| Vezz me on Abstract / Opinion | Screening methodology caveats and briefing Case Law opinions with zero page clutter | Triggered intentionally via custom shortcut |
| Extensions injecting badges on every SERP row | Seeing citation counts inline | Clutters Google Scholar's clean layout and requires broad host permissions |
| Downloading 30 PDFs to read later | Offline archival | Wastes hours downloading papers with flawed or irrelevant methods |
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